I get over and ride along the river about 6 times a year. Try taking MO. 79 south out of Hannibal and then pick up County W at Clarksville and ride it south to RT.47. Good roads with little traffic. There are also several good county roads that intersect county W and run between RT.79 and MO.61. You'll be in the bluffs along the river the whole time. Not much traffic but keep an eye out for farm equipment and wildlife. I've seen both while in the area. Maybe I'll see you on the road sometime. Enjoy!